Symansis - Products - cal cal cal

By: Symansis  06-Dec-2011
Keywords: Tumor Cell

A specific small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities.   PI3K-delta inhibitor CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic   (lymphocytes) lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.

CAL-101 is a potent PI3K p110d inhibitor with an IC50 of  2.5 nM

Keywords: Tumor Cell

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Symansis - Products - pyrvinium tosylate

The paper shows that pyrvinium binds all casein kinase 1 family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1a kinase activity. Thus representing a more potent inhibitor of the Wnt/betacatenin signaling pathway than other compounds currently available. This was recently described as an activator of CK-1alpha that subsequently blocked beta-catenin signaling.


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Symansis - Products

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